Embryology & Early Development
Neural fold
The neural folds are the raised edges of the neural plate that rise up and meet to close the neural tube.
In short: Neural fold
- Their meeting and fusion closes the neural tube.
- Failure of fusion contributes to neural tube defects.
- They are part of neurulation.
- They form the edges of the folding neural plate.
What it is
They are the rising edges of the folding neural plate. As the plate folds, its two edges (the neural folds) lift up, move toward each other, and fuse to close the tube.
Understanding Neural fold
When the neural folds meet and fuse properly, the neural tube closes; failure of this fusion at the head end can contribute to cranial neural tube defects like encephalocele. This fusion is a key moment in neurulation, and where it fails determines the type and location of the resulting defect.
Why it matters
Understanding the neural folds helps families see how the neural tube closes and how a failure of the folds to fuse can lead to an encephalocele.
Common questions
What do the neural folds do?
Rise and fuse to close the neural tube.
What if they don't fuse?
A neural tube defect can result.
When does this happen?
During neurulation, in early pregnancy.
Bottom line
The neural folds rise and fuse to close the neural tube, and failed fusion contributes to defects.
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