Associated Conditions & Findings
Anencephaly
Anencephaly is a severe neural tube defect in which major parts of the brain and skull do not form.
In short: Anencephaly
- It results from failure of the head end of the neural tube to close.
- It is a severe cranial neural tube defect.
- Folic acid reduces its risk.
- It is mentioned to place encephalocele in context.
What it is
It is a severe neural tube defect in which major parts of the brain and skull do not develop, resulting from failure of the head-end of the neural tube to close. It is one of the most severe neural tube defects.
Understanding Anencephaly
Like encephalocele, anencephaly arises from a head-end (anterior) neural tube closure problem, but it is far more severe, as major brain structures do not form. Folic acid clearly reduces its risk. It is mentioned here, with sensitivity, to place encephalocele within the spectrum of cranial neural tube defects — encephalocele being a distinct and generally less severe condition.
Why it matters
Understanding anencephaly helps families see the range of cranial neural tube defects and distinguish encephalocele, which is a separate condition, from this much more severe one. It also reinforces why folic acid is part of prevention.
Common questions
Is anencephaly the same as encephalocele?
No — both are cranial neural tube defects, but they are distinct, and anencephaly is far more severe.
What causes it?
Failure of the head end of the neural tube to close.
Does folic acid help prevent it?
Yes, clearly.
Bottom line
Anencephaly is a severe cranial neural tube defect distinct from encephalocele, where major brain structures do not form.
Browse all 265 Encephalocele definitions
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