Lomustine (CCNU)

What it is

Lomustine (also known as CCNU) is a chemotherapy drug used for some gliomas, particularly at recurrence. It is taken by mouth as a pill, can cross the blood-brain barrier to reach brain tumors, and is one of the drugs in the PCV regimen.

Understanding Lomustine (CCNU)

Lomustine belongs to a class of chemotherapy drugs (nitrosoureas) that can penetrate the brain, making them useful for brain tumors. It is an oral drug, typically given on a cycle (for example, once every several weeks), allowing recovery between doses. Lomustine is used in several settings: as part of the PCV combination (for oligodendrogliomas and other tumors), and as a single agent or in combination at the time of glioblastoma recurrence, where it is a commonly used option. Its main side effect to monitor is a delayed effect on blood counts, so blood is checked between cycles, and it can have other effects that are managed. The choice to use lomustine depends on the tumor type and situation, especially when initial treatments have been used and the tumor has recurred. Lomustine is an established brain-penetrating chemotherapy option. Understanding lomustine in gliomas clarifies a brain-penetrating chemotherapy drug used especially at recurrence.

Why it matters

Understanding lomustine helps patients and families see a brain-penetrating chemotherapy option — an oral pill used in combination regimens and especially at glioblastoma recurrence — as part of the range of treatment options.