End-to-end stack for the most lethal primary brain tumor.
Glioblastoma and lower-grade gliomas remain the deadliest primary brain cancers. AURORA-GLIO unifies molecular profiling, radiomics, surgical planning, ethics and clinical translation into a single auditable, open pipeline.
Glioma is the most common malignant primary brain tumor in adults. Median survival in glioblastoma sits around 15 months despite four decades of trials. Heterogeneity — across patients and inside a single tumor — is the central problem AURORA-GLIO is built to address.
What a node running AURORA-GLIO is designed to do, from connecting a source to signing off on what may leave the building. Six steps, drawing on the module's 11 specified subsystems at step three.
The console below is a design mock, not a screenshot of running software. Status pills such as “connected” and “running” depict intended states, and every identifier, count and score is fabricated for demonstration — no patient data, no measured performance, no clinical output. What the sequence is meant to show is where the human sits and what the boundary permits.
aurora-node · demo-site.internal
egress: aggregates only
Connect the sources you already have
step 1 of 6
The node reads your PACS and FHIR endpoint from inside your network. Nothing is copied out, and no inbound path to patient data is opened from outside.
11 subsystems, each a vertical slice with its own specification. The states below track build progress against that spec — they are not evaluation results and not regulatory status. Module readiness overall: “Spec frozen · prototypes building”.
01Systems AtlasGLIO-SYSMulti-omic systems map of glial lineages, niches and signalling.Live
02Macro-Micro BridgeGLIO-MMBConnects scanner-scale imaging with cell-scale histology features.Live
03Tumor MicroenvironmentGLIO-TMEImmune-stromal-vascular crosstalk simulator with spatial priors.Live
04Foundation ModelsGLIO-AIPre-trained vision-language-omics transformer for glioma.Live
05Infiltration FieldGLIO-INFILDiffusion-reaction PDE solver for invasive margins beyond contrast.Live
06Causal TrajectoriesGLIO-CAUSCounterfactual graphs over treatment, resection and progression.Beta
07Integrated DiagnosisGLIO-DIAGWHO-aligned molecular + histo + radio diagnostic synthesizer.Live
08Radiotherapy PlanGLIO-RADAuto-contoured GTV/CTV/PTV with dose-response priors.Beta
09Clinical TrialsGLIO-CLINEligibility matcher and adaptive arm allocator for active studies.Beta
10Ethics & GovernanceGLIO-ETHICBias, consent and equity audit layer with provenance reports.Live
11Organoid TwinGLIO-ORGPatient-derived organoid digital twin synced with bench data.Soon
For patients and families
The same condition, written for the people living with it: 50 plain-language guides and 265 defined terms, with no methodology and no jargon left unexplained.
Every module must move through the same four gates before any clinical use, and each gate can send it back rather than forward.
No AURORA module has entered this pathway. Every gate below reads not started, and will continue to until a real result is published and the site that produced it has agreed to be named. Build progress on the subsystems above is not evidence of clinical validity.
1Retrospective validationNot startedHeld-out data from sites that took no part in development.
2Silent prospectiveNot startedRuns alongside standard care with no output shown to clinicians.
3Supervised clinical evaluationNot startedProspective, under ethics approval, reported to DECIDE-AI.
4Post-market monitoringNot startedContinuous performance and drift tracking; degradation withdraws the module.
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