Working papers
One paper per subsystem, written by the team that built it. Filter by module, or read the whole set.
Worked examples of the index format. Titles and statuses show how entries will be presented; none is a published paper yet.
Papers are listed here once a draft exists. Subsystems still in design do not get a placeholder entry — an empty row would imply work that hasn't happened.
RFC index
Every governance and design decision is proposed in public before it lands. Anyone can open one; the council reads all of them, and patient advocates vote alongside clinical and technical members.
Example RFCs illustrating the format and the kinds of decision that go through it. No RFC below has been ratified by the council — the states shown are illustrative.
Datasets & registries
Cohorts are described publicly and queried where they live. No dataset listed here is downloadable from us, because no dataset listed here is held by us — the description is the shared artefact, not the data.
Example cohort descriptions showing the metadata each one carries. Names, site counts and scales are illustrative; no cohort below is currently enrolled.
Replication tracker
The uncomfortable table. Every headline result is re-run at a site that had no part in producing it, and the outcome is published either way — including when performance drops.
The rows below are worked examples, deliberately including a weakened and a failed outcome to show that those get published too. The deltas are not measurements, and sites stay unattributed until a real result exists and that site has agreed to be named.
Open questions
The things we don't know, stated plainly. Patients ask these constantly and the honest answer is that the field cannot yet answer them — which is exactly why they are the research agenda.
Do imaging-derived tumour features survive a change of scanner?
AURORA-GLIOOur own replication says: often not. A feature that works only on the scanner it was developed on is a publication, not a tool.
See the replication result →What outcome measures actually matter to patients over a lifetime?
GovernanceMost registries record what is easy to record. Patient advocates on the council have consistently said the recorded endpoints are not the ones they live with.
Governance & ethics →Figures quoted on auroraneuro.org
The landing page's "field, in five numbers" section quotes public reports. Every figure traces to one of the sources below; none is a measurement by AURORA, and figures are for the United States unless stated.
- 1Ostrom et al., CBTRUS Statistical Report: Primary Brain and Other CNS Tumors Diagnosed in the United States in 2018–2022. Neuro-Oncology, 2025.
- 2National Brain Tumor Society, Brain Tumor Facts (glioblastoma 5-year relative survival 7.0%, median survival 8 months, 52.2% of malignant tumors).
- 3Analysis of challenges to accrual in clinical trials for newly diagnosed glioblastoma (INNV-15), Neuro-Oncology abstracts, 2018: incidence 3.2 per 100,000, ~12,500 diagnoses a year, 8–11% enrolment.
- 4CBTRUS Fact Sheet: median observed survival in glioblastoma, 8 months.
- 5Vanderbeek et al., The clinical trials landscape for glioblastoma: is it adequate to develop new treatments? Neuro-Oncology 20(8), 2018.
- 6Liu, Wasilewski, Mohile. Disparities in patient enrollment on glioblastoma clinical trials. CNS Oncology 9(2), 2020: median trial age 54.0, 10.05 years below CBTRUS.
- 7Predicting therapeutic clinical trial enrollment for adult glioma with supervised machine learning (PMC), citing incidence-specific under-accrual of women (44.1% vs 37.7%) and minority patients (16.9% vs 5.9%).
Nothing on this site diagnoses, recommends treatment, triages care or enrols participants.
How to cite AURORA
Cite the module and version you actually used, not the project in general — module behaviour changes between versions, and a citation that can't be pinned to one isn't reproducible.
@software{aurora_glio_2026,
title = {AURORA-GLIO: computational research infrastructure for glioma},
author = {{AURORA Collective}},
year = {2026},
version = {0.1.0-pilot},
note = {Research use only. Not a certified medical device.},
url = {https://github.com/AURORA-NEURO}
}