← AURORA-GLIO · GliomaSUBSYSTEM 02 / 11
GLIO-MMB

Macro-Micro Bridge

Connects scanner-scale imaging with cell-scale histology features.

Connects scanner-scale imaging with cell-scale histology features.

liveAURORA-GLIOpilotalpha · open at public alpha
SubsystemGLIO-MMB
Status live
Readinessalpha · open at public alpha
Anchored inBakas 2017 · Capper 2018 · Kickingereder 2019
LicenseMIT @ public alpha
Packageaurora-glio[mmb]
I · Overview

Macro-Micro Bridge, in context.

GLIO-MMB is one of 11 subsystems that compose AURORA-GLIO. It is independently usable but shares the same patient representation, provenance log and governance layer as every other AURORA module.

Two truths sit in the same head: a contrast-enhancing region on an MRI and a slice of tissue under a microscope. They describe the same disease. Almost nothing today reads them together. GLIO-MMB is the bridge.

02
Subsystem index
11
Module total
live
Pilot status
MIT
License @ public alpha
II · What it does

A longer look.

Mechanically, it is a cross-modal embedding stack that aligns radiomic and histological features through learned correspondences and explicit anatomical priors. It is conservative on purpose. The bridge prefers to say 'I don't know' over hallucinating a correspondence — particularly across resolution scales where vision-language models have a track record of overconfidence.

III · Install

Install just this subsystem.

GLIO-MMB can be installed standalone, or pulled in as part of the full AURORA-GLIO stack. Both ship the same code and weights, signed end-to-end. Pilot partners have access today; public alpha opens Q4 2026.

~ / aurora · glio-mmb$ copy
pip install aurora-glio[mmb]
aurora glio.mmb align \
  --mri case.nii.gz \
  --wsi case.svs \
  --report report.pdf
Package
aurora-glio[mmb]
Hardware
CPU · NVIDIA · Apple silicon
Deploys
Cloud · On-prem · Air-gapped
Signed
Sigstore · sha256 pinned

Eight diseases is the beginning.

AURORA is in private pilot today and opens to the world at public alpha in Q4 2026 under MIT. If you carry the weight of these diseases — as a clinician, scientist, builder, patient or advocate — there is a seat at the table.