Immune-stromal-vascular crosstalk simulator with spatial priors.
Immune-stromal-vascular crosstalk simulator with spatial priors.
GLIO-TME is one of 11 subsystems that compose AURORA-GLIO. It is independently usable but shares the same patient representation, provenance log and governance layer as every other AURORA module.
Immune escape is the central unsolved problem in glioblastoma. The microenvironment is where it happens. GLIO-TME is a simulator over the immune-stromal-vascular crosstalk that defines the tumor's local context, parameterised against open single-cell and spatial datasets.
It is not a black box. The simulator surfaces interpretable populations and rates; the priors are explicit; the outputs are calibrated against published cohorts. Where the literature splits — and it splits often — the module reports the band, not the centre.
GLIO-TME can be installed standalone, or pulled in as part of the full AURORA-GLIO stack. Both ship the same code and weights, signed end-to-end. Pilot partners have access today; public alpha opens Q4 2026.
pip install aurora-glio[tme] aurora glio.tme simulate \ --case case.aurora \ --horizon 180d
GLIO-TME moves faster when the right people are in the room. Whether you carry a service line, a registry, or a few quiet weekends — there is a way in.
Sponsor GLIO-TME for your unit. Co-design the surface, the audit log and the override semantics with the team that built it. Pilot sponsors keep a council seat for the duration.
Run a research question on GLIO-TME. Federation means you can train across populations you cannot see alone. Whitepapers carry co-authorship, not acknowledgements.
GLIO-TME ships starter tasks tagged 'good-first-issue' on the pilot repo. SDKs in Python, TypeScript and Rust at public alpha. MIT, no CLA.
AURORA is in private pilot today and opens to the world at public alpha in Q4 2026 under MIT. If you carry the weight of these diseases — as a clinician, scientist, builder, patient or advocate — there is a seat at the table.